![]() 4 The effect of patient genetic polymorphism in relation to intestinal CYP3A4 concentration makes for an interaction that is highly difficult to predict from patient to patient regardless of the amount or concentration of grapefruit consumed. 2 Another study demonstrated that the inhibition of CYP3A4 can persist for 24 to 72 hours, 3 whereas Takanaga and colleagues have shown the interaction to persist for 72 hours. (For an extensive list of drugs affected by grapefruit juice. For example, one study has shown that intestinal CYP3A4 concentration can be decreased by 47 percent within four hours of grapefruit consumption. This enzyme breaks down a wide array of medications, including atorvastatin (Lipitor). We also feel that the evidence reported in the literature is unclear in describing the magnitude and duration of the effect of grapefruit on the intestinal cytochrome P450 3A4 (CYP3A4) isoenzyme system. Grapefruit juice inhibits the CYP3A4 enzyme of the cytochrome P450 system in the intestinal mucosa, increasing the bioavailability of drugs with a high first. This condition affects less than 0.1 of people taking statins. We are also aware of this and consequently labeled our key recommendations for practice with a SORT evidence rating of C (consensus, disease-oriented evidence, usual practice, expert opinion, or case series). Consuming grapefruit or grapefruit juice when taking statins comes with a rare but serious risk of rhabdomyolysis. Reamy and Stephens are rightly concerned about the lack of clinical and patient-oriented outcomes regarding grapefruit interactions. ![]() Even patients who enjoy grapefruit juice do not ingest more than one quart each day! Additionally, one study cited by the authors showed that when simvastatin was taken 24 hours after ingestion of the same large volume (1,200 mL) of grapefruit juice, the effect of grapefruit juice on the concentration of simvastatin was only 10 percent of that when the statin and juice were taken concomitantly. ![]() Specifically, 200 mL of double-strength juice was consumed three times per day, which equates to 1,200 mL (40 oz) per day of regular-strength grapefruit juice. Statin medications have made it possible for many people to live longer and healthier lives, but it is grapefruit interaction with atorvastatin to pay attention. The cited studies also used high-dose statins (80 mg of lovastatin, 60 mg of simvastatin) and unrealistically high volumes of grapefruit juice. Whether there is a log-linear relationship between serum concentration and clinical morbidity is a matter of debate. An additional, and perhaps more significant concern is that these studies demonstrated no clinical or patient-oriented outcomes they merely reported increased serum concentrations of lovastatin (Mevacor) and simvastatin (Zocor). ![]()
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![]() It takes a woman to do that kind of work." Chapter 13, Pg. Scout says that she "know now what he was trying to do, but Atticus was only a man. When he had said that, Scout had felt like the old Atticus was back. As he had talked, he had realized the ludicrous request Alexandra had made on him and his children and told them to ignore what he'd said. His behavior and his request didn't seem like the Atticus they loved at all. Atticus tried to explain to them how they should behave being from a family of gentle breeding, and as he talked, he fidgeted uncomfortably and cleared his throat. When it became obvious to her that Scout and Jem had no sense of pride concerning their heritage as well as no sense of duty to their name, she insisted that Atticus explain to them that they were Finches and they should behave like it. She was an active part of the neighborhood, and she brought with her a sense of the social hierarchy of Maycomb County. Alexandra moved right in and made herself at home, and soon enough it seemed as if she'd lived there forever. Both novels have a troublemaking child as their protagonist and narrator, and both novels chart their protagonists’ growth as their adventures force them to see the unfairness and brutality of their community and of society, particularly in regard to the racist treatment of black Americans.Alexandra announced that she'd be staying with them because she and Atticus had decided that it was time the children had a feminine influence in their home. To Kill a Mockingbird also shares many connections with Huckleberry Finn by Mark Twain. It’s set 20 years after the events of Mockingbird. In 2015, Lee’s publisher released Go Set a Watchman, which was billed as a sequel to Mockingbird but was actually her first draft of Mockingbird. Other notable works of Southern literature include Margaret Mitchell's Gone with the Wind, William Faulkner's The Sound and the Fury, and Flannery O'Connor's A Good Man is Hard to Find. Mockingbird therefore falls into a particular subset of American literature called Southern literature, since it deals explicitly and implicitly with themes and issues that were uniquely Southern. While it is the story of Scout’s growing up, it is also a story of the racially charged atmosphere in the town in the years of the Great Depression. To Kill a Mockingbird is set in the fictional town of Maycomb, Alabama. Lee died in her sleep in 2016 at age 89, having received numerous honorary degrees, the Presidential Medal of Freedom, and the National Medal of Arts. ![]() Its publication was controversial, as some believed Lee’s publisher took advantage of her old age to release the book (though an investigation by the State of Alabama found no evidence of this). At that point, her publisher released Go Set a Watchman, which Lee wrote initially as a first draft of Mockingbird. ![]() Aside from a few essays, she published nothing else until 2015. After 1960, Lee retreated from public life to her hometown of Monroeville, Alabama. She published To Kill a Mockingbird in 1960, which became an immediate and immense success-it won the Pulitzer Prize for Fiction in 1961 and was voted “Best Novel of the Century” by a Library Journal poll in 1999. Background Information: Provide a sentence or two that leads your AGIS into your thesis. ![]() Set up the paper with a background story or interesting quote from the book. She earned a law degree from the University of Alabama in 1949 and spent a year in Oxford, England, but moved to New York in 1950 to focus on writing. To Kill a Mockingbird Essay Outline Explanation Introduction Attention Grabbing Introductory Sentence (s)/Hook: Introduce your topic uniquely by grabbing the audience’s attention. Nelle Harper Lee was the youngest of four children born to Amasa Lee and Frances Finch Lee. ![]() ![]() The next entry in the Sims series is this year's The Sims 4, which comes to PC on September 2. If you want to remove the standard Sims 2 from your game library, all you need to do is right-click on the game and select "hide tile." It includes the main game, as well as every expansion pack for The Sims 2 ever released. The Sims 2 Ultimate Collection, as its name suggests, is an all-encompassing bundle. All you need to do is log in to Origin and visit your My Games library to see the free game. #The sims 2 super collection free for free#"If you have a problem with your game, you are of course still welcome to contact us here at EA Help," the company said.Īs for the free upgrade to The Sims 2 Ultimate Collection, anyone who owns a digital copy of The Sims 2 will receive the premium pack for free sometime in the next five days. The Sims 2 is a 2004 strategic life simulation video game developed by. With it you create a living zone of your style with a house, great and happy neighbourhood, other Sims, and even set up a family dynasty. The Sims 2: Super Collection 12+ Your faves in one place Aspyr Media, Inc. In The Sims 2 Super Collection MAC Game, you raise you Sim from a toddler to until he makes It to Its grave. Of course, if you encounter an issue with the game, EA isn't turning its back to you. The Sims 2: Ultimate Collection Free Download Full PC Game Direct Link for Windows. The Sims 2: Super Collection 1.2.2 MacOSX Free Download. Electronic Arts announced today that it is ending support for 2004 life-simulation game The Sims 2, also revealing that owners of digital copies will be upgraded to the Ultimate Collection at no extra cost.ĮA announced the news on its support site today, saying the company will no longer provide any new content for The Sims 2 or release any additional technical updates for the game. ![]() ![]() ![]()
Will deliver a "knock-out punch" to NT this year.) Torvalds may be enthusiastic about the commercialization of freeware, but he's not motivated by it. (The Linux vendor Caldera recently issued a spiritedĬhallenge to Microsoft on its Web site, saying that its OpenLinux products #Mmass source code windows#That marriage has pushed the Linux user base to about 5 million, by his estimation, to rival Windows NT, Microsoft's up-and-coming It's a marriage made in heaven," he says. "There are two different types of development and both are needed. #Mmass source code free#In his corner of a world where religious wars flare every day, Torvalds, who created Linux at the University of Helsinki but now works in the heart of Silicon Valley, is remarkably relaxed about the philosophy of free software. #Mmass source code for free#Linux, Linus's name mixed with Unix, is eitherĪvailable for free as source code on the Internet or for a relatively modest fee-often less than $100-from companies that package it on CD-ROM, document it, make it easy to install, and even add extras such as office applications and server software. ![]() "Lots of people think it's strange that the commercial companies are making money from the work of the technical people, but everybody gets what he wants out the project," said Linus Torvalds, the creator of Linux, an eight-year-old Unix-based operating system for PCs. #Mmass source code software#Its moneymaking server products will remain proprietary, but even a limited free software strategy could help Netscape turn the corner, along with the profile of the freeware movement. Netscape's strategy for incorporating the freeware philosophy into its upcoming release of Communicator will be closely watched on both sides. It is this development that has led to the consternation of some and the applause of others. The projects remain mostly under the guidance of technology enthusiasts, but commercial interests have gained a toehold. Not only for all to see, but also to use, manipulate, change, and redistribute-sometimes free of charge, sometimes for a fee-but always with the knowledge that there are few, if any, secrets. Their respective source codes are published What the projects all have in common is openness. The Internet and their love of technology. The freeware philosophy places the responsibility of creating, changing, and debugging complex systems in the hands of complete strangers linked only by Manyįounders and early users of the Internet have turned to technology toĭevelop their personal philosophies, and this spirit of communal innovationįor its own sake has played a significant role in the tremendous growth ofĭuring the past two decades, the freeware idea has resulted in numerous software projects, generating names such as Apache, GNU (which stands for the solipsistic "GNU's Not Unix"), and Linux. Maverick political nature as much as it is a function of technology. The freeware concept, really a religion of sorts, is reflective of the industry's ![]() Understand the concept, you should think of free speech, not free beer," Richard Stallman, one of the pioneers of the movement, The notion of freeware or free software doesn't mean free in the financial sense, but instead applies to distribution, exchanging code, and innovation. "It's going to teach a whole generation of programmers about this idea." "This is a win for Netscape, for the industry, and a step forward for 'software-kind,'" as one Internet software development manager in Silicon Valley put it. Handful of companies, the "freeware" model of development suddenly took center stage two weeks ago when Netscape Communications said it would give away the source code of its forthcoming Communicator suite, including one of the most popular software programs ever: the Navigator browser. Once mostly the domain of code warriors, academics, and Throughout the normally staid hallways and labs of their high-technology offices, engineers were abuzz with anticipation that the computer establishment might finally sit up and take notice of a software philosophy that has quietly gained ground for the past two decades. ![]() ![]() ![]() NOTE: The 10g carbs for fast fat loss is a stretch goal. If your protein goal isn't in this ballpark, adjust body fat percentage until it is. Men 5 foot tall start at 100g protein and add 5g per inch of height. Women 5 foot tall start around 80-90g protein then add 5g protein per inch of height. MyFitnessPal has dominated in digital food tracking for years but did you know there's an alternative An alternative that may be superior to MFP Today's episode is a breakdown between MyFitnessPal and Cronometer, micronutrient considerations, user-friendliness, and more Topics include: - MyFitnessPal vs Cronometer - Cronometer Discount - Comparing MyFitnessPal vs Cronometer - Zooming Out. To check if you are in the right range for your protein goal, use this rule of thumb. ![]() If you don't, select "NO" and enter all the measurements. For me, while I like that Chronometer gives more micronutrient data, at the end of the day I still personally prefer Myfitnesspal because it is possible to separate timing of meals each day and. ![]() (under 10 years old only the protein target is given for reference)īody Fat Percentage: It is important to get body fat percentage as accurate as possible. If you know it accurately you can enter it. Back to Chronometer vs Myfitnesspal At the end of the day, any app you use has to be something that you find easy enough to do, helpful and useful. Beyond the basics of tracking Macros, my deficit number is the most important number I track during weight loss. Protein is a goal, fat and carbs are a limit to stay under and Carbs are total carbs, not net carbs. The minimum fat you need is 30-40 grams a day to ensure vitamin absorption and hormone production. Viewing Daily/Weekly Stats: While it took me a couple of days to get used to the more graphical way Cronometer presents data vs the more tabular way MFP provides, I've found Cronometer to be easily readable, and also shows key data points, like daily/weekly/monthly calorie deficits more clearly and easily than MFP. Cronometer Macro and micronutrient table is clear Foods are entered as one long list Its not possible to separate foods into meals or figure out the timing. NOTE: Set to sedentary for fastest fat loss and set to Fast Weight Loss with PSMF for best fat loss results. " At the end of the day, it's really a matter of forming lifelong, sustainable habits.This calculator incorporates all the knowledge and experience from 20 years of using keto to help clients. "People shouldn't be obsessed ," he said. Tracking physical activity can help people set goals and learn new behaviors, but it shouldn't be a reason to change healthy eating patterns. Cronometer helps you develop healthy habits by. Michaelides added that no nutrition app should tell people to consume extra calories because they've exercised. Cronometers nutrition & calorie tracker is here to support you reach your health or weight loss goals. " A lot of the calories in food are buried inside their meal." " Most people, without the assistance of a food database, would not be equipped to know the big picture," Michaelides said. Unless someone has a clinical diagnosis and needs to track their micronutrients, he said, it's more important to form healthy, lifelong habits. "I t's really about changing your behavior." " Weight loss is a lot more than just writing things down," said Andreas Michaelides, Noom's chief psychology officer. The app provides users with "coaches" who motivate them to meet their nutrition goals. Noom is different from the other apps in its focus on wellness as opposed to traditional dieting. Additionally, it's difficult to assess the nutrient quality of an individual's diet, since few nutrients are included in the database. The Noom app doesn't show users their levels of micronutrients (like calcium, iron, and vitamin C) or macronutrients (carbs, protein, and fat), but its overall calorie estimates are pretty spot-on. Professionally speaking, I find the information unreliable in MFP given how many entries for the same food there are. ![]() |
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